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Effects of Overexpression of the Endogenous Farnesyl Diphosphate Synthase on the Artemisinin Content in Artemisia annua L.
Author(s) -
Han JunLi,
Liu BenYe,
Ye HeChun,
Wang Hong,
Li ZhenQiu,
Li GuoFeng
Publication year - 2006
Publication title -
journal of integrative plant biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.734
H-Index - 83
eISSN - 1744-7909
pISSN - 1672-9072
DOI - 10.1111/j.1744-7909.2006.00208.x
Subject(s) - artemisia annua , artemisinin , farnesyl diphosphate synthase , chemistry , traditional medicine , yield (engineering) , biology , atp synthase , pharmacology , biochemistry , plasmodium falciparum , medicine , malaria , enzyme , materials science , immunology , metallurgy
Artemisinin is a novel effective antimalarial drug extracted from the medicinal plant Artemisia annua L. Owing to the tight market and low yield of artemisinin, there is great interest in enhancing the production of artemisinin. In the present study, farnesyl diphosphate synthase (FPS) was overexpressed in high‐yield A. annua to increase the artemisinin content. The FPS activity in transgenic A. annua was two‐ to threefold greater than that in non‐transgenic A. annua. The highest artemisinin content in transgenic A. annua was approximately 0.9% (dry weight), which was 34.4% higher than that in non‐transgenic A. annua. The results demonstrate the regulatory role of FPS in artemisinin biosynthesis. (Managing editor: Wei Wang)