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Norditerpenoid Alkaloids from Aconitum spicatum Stapf
Author(s) -
Gao LiMing,
Yan HaiYan,
He YangQing,
Wei XiaoMei
Publication year - 2006
Publication title -
journal of integrative plant biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.734
H-Index - 83
eISSN - 1744-7909
pISSN - 1672-9072
DOI - 10.1111/j.1744-7909.2006.00178.x
Subject(s) - aconitum , ranunculaceae , stereochemistry , chemistry , terpenoid , alkaloid , traditional medicine , biology , botany , medicine
To search for pharmacologically and structurally interesting substances from traditional Chinese medicines, we investigated the chemical compounds of Aconitum spicatum Stapf. Two new norditerpenoid alkaloids, namely spicatine A (compound 1) and spicatine B (compound 2), as well as 11 known norditerpenoid alkaloids were isolated from the CHCl 3 portion of the 90% ethanol extract of the roots of A. spicatum. The structures of the alkaloids were characterized on the basis of their spectral data. One of the isolated compounds showed significant cytotoxic activities (IC50 values < 200 μmol/L) against the HL‐60 cell line. (Managing editor: Wei Wang)