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Glycosides from Roots of Cyathula officinalis Kuan
Author(s) -
ZHOU Rong,
LI BoGang,
ZHANG GuoLin
Publication year - 2005
Publication title -
journal of integrative plant biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.734
H-Index - 83
eISSN - 1744-7909
pISSN - 1672-9072
DOI - 10.1111/j.1744-7909.2005.00048.x
Subject(s) - oleanolic acid , hederagenin , chemistry , glycoside , officinalis , traditional medicine , stereochemistry , medicine , alternative medicine , pathology
To search for new and bioactive compounds from traditional Chinese medicines, a new glycoside, 3‐O‐[α‐ L ‐rhamnopyranosyl‐(1→3)‐( n ‐butyl‐β‐ D ‐glucopyranosiduronate)]‐28‐O‐β‐ D ‐glucopyranosyloleanolic acid ( 1 ), was isolated from the roots of Cyathula officinalis Kuan, along with 3‐O‐(methyl‐β‐ D ‐glucopyranosiduronate)‐28‐O‐β‐ D ‐glucopyranosyl oleanolic acid ( 2 ), 3‐O‐β‐ D ‐glucopyranosyl oleanolic acid ( 3 ), 3‐O‐β‐ D ‐glucuronopyranosyl oleanolic acid ( 4 ), 3‐O‐[β‐ L ‐rhamnopyranosyl‐(1→3)‐(β‐ D ‐glucuronopyranosyl)] oleanolic acid ( 5 ), 3‐O‐(β‐ D ‐glucuronopyranosyl)‐28‐O‐β‐ D ‐glucopyranosyl oleanolic acid ( 6 ), 28‐O‐β‐ D ‐glucuronopyranosyl‐(1→4)‐β‐ D ‐glucopyranosyl hederagenin ( 7 ), 3‐O‐[β‐ L ‐rhamnopyranosyl‐(1→3)‐β‐ D ‐glucuronopyranosyl]‐28‐O‐β‐ D ‐glucopyranosyl oleanolic acid ( 8 ), and 3‐O‐[β‐ D ‐glucopyranosyl‐(1→2)‐α‐ L ‐rhamnopyranosyl‐(1→3)‐β‐ D ‐glucuronopyranosyl]‐28‐O‐β‐ D ‐glucopyranosyl oleanolic acid ( 9 ). The structures of these compounds were determined based on spectral and chemical evidence. The 50 per cent growth‐inhibiting (GI 50 ) of compounds 1 and 5 against MDA‐MB‐231 (a human breast cancer cell line) was 3.44 × 10 ‐4 and 4.66 × 10 ‐4 mol/L, respectively. (Managing editor: Wei WANG)