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In Vitro Cytotoxicity of Rare Earth Oxide Nanoparticles for Imaging Applications
Author(s) -
Petrochenko Peter E.,
Zhang Qin,
Wang Haorong,
Sun Ted,
Wildt Bridget,
Betz Martha W.,
Goering Peter L.,
Narayan Roger J.
Publication year - 2012
Publication title -
international journal of applied ceramic technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 57
eISSN - 1744-7402
pISSN - 1546-542X
DOI - 10.1111/j.1744-7402.2012.02784.x
Subject(s) - cytotoxicity , samarium , materials science , nuclear chemistry , toxicity , nanoparticle , surface modification , rare earth , mtt assay , in vitro , nanotechnology , chemistry , inorganic chemistry , organic chemistry , metallurgy , biochemistry
The in vitro cytotoxicity and cellular uptake of commercially available doped YVO 4 were evaluated in RAW 264.7 macrophages using the MTT assay. The results indicated that 20–50 nm diameter samarium‐doped YVO 4 showed significant toxicity at concentrations of 25 μg/mL and higher; samples of the same material functionalized with COOH showed less cytotoxicity. At concentrations of 25–100 μg/mL, 20–50 nm erbium‐doped YVO 4 showed less toxicity compared with 20–50 nm samarium‐doped YVO 4 . Ten nanometer samples showed no toxicity at concentrations of 100–600 μg/mL. The cytotoxicity of rare earth nanoparticles in macrophages is dependent, at least in part, on size and surface functionalization.