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Osteogenesis of a Bioactive Ceramic‐Calcium Phosphosilicate Composite System in Goat Femur Defect
Author(s) -
John Annie,
Mani Susan,
Gopalakrishnan Sandeep,
Babu Suresh,
Lal Arthur V.,
Varma Harikrishna
Publication year - 2011
Publication title -
international journal of applied ceramic technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 57
eISSN - 1744-7402
pISSN - 1546-542X
DOI - 10.1111/j.1744-7402.2011.02622.x
Subject(s) - materials science , composite number , ceramic , calcium silicate , resorption , femur , calcium , ceramic composite , biomedical engineering , bone resorption , in vivo , composite material , metallurgy , surgery , biology , medicine , microbiology and biotechnology
In spite of the array of synthetic bone grafts available, the pursuit for an ideal graft continues. In view of this, a synthetic bioactive calcium phosphosilicate composite (HABGS) has been developed combining the properties of hydroxyapatite and silicate system. The in vivo performance of HABGS granules in goat femur defect stimulated a favorable environment for de novo bone formation with faster resorption. The ceramic composite is attractive for its low Si content together with its negligible levels at implanted sites and vital organs postimplantation. Herein, we propose the safety and efficacy of this composite as a promising bone substitute.