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Fatty Acid Conjugated Calcium Phosphate Nanoparticles for Protein Delivery
Author(s) -
Paul Willi,
Sharma Chandra P.
Publication year - 2010
Publication title -
international journal of applied ceramic technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 57
eISSN - 1744-7402
pISSN - 1546-542X
DOI - 10.1111/j.1744-7402.2009.02442.x
Subject(s) - lauric acid , conjugated system , nanoparticle , calcium , materials science , phosphate , chitosan , nuclear chemistry , insulin , fatty acid , chemical engineering , biochemistry , chemistry , nanotechnology , polymer , biology , engineering , metallurgy , composite material , endocrinology
Calcium phosphate (CaP) nanoparticles with particle sizes <100 nm were prepared and conjugated with lauric acid. This was achieved by first activating the phosphate group of CaP and conjugating it with lauric acid via acid chloride route incorporating chitosan as a spacer. Insulin was loaded and the nanoparticles were coated with alginate to impart pH‐dependent sustained release. The released insulin was stable without alteration of the conformation of insulin and the particles were found to be noncytotoxic. Thus these CaP nanoparticles may be used as an excellent carrier for delivering protein drugs particularly insulin orally.