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Grafting of 2‐Hydroxypropyl‐β‐Cyclodextrin on Gum Arabic‐Modified Iron Oxide Nanoparticles as a Magnetic Carrier for Targeted Delivery of Hydrophobic Anticancer Drug
Author(s) -
Banerjee Shashwat S.,
Chen DongHwang
Publication year - 2010
Publication title -
international journal of applied ceramic technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 57
eISSN - 1744-7402
pISSN - 1546-542X
DOI - 10.1111/j.1744-7402.2008.02332.x
Subject(s) - nanocarriers , grafting , cyclodextrin , materials science , targeted drug delivery , drug delivery , biocompatibility , linker , magnetic nanoparticles , nanoparticle , nanotechnology , combinatorial chemistry , chemistry , organic chemistry , polymer , computer science , metallurgy , composite material , operating system
A new magnetic nanocarrier for the targeted delivery of hydrophobic drugs was developed by modifying magnetic nanoparticles with gum arabic and grafting with 2‐hydroxypropyl‐cyclodextrins (HCD) using hexamethylene diisocyanate (HMDI) as a linker. The size, hydrodynamic diameter, and grafting of HCD were characterized. The resultant magnetic nanocarrier exhibited an excellent capability to load all‐trans‐retinoic acid (ATRA), an anticancer agent. The better biocompatibility and the combined properties of specific targeting and complexation ability with hydrophobic drugs make the nanosystem an exciting prospect for targeted delivery of hydrophobic drugs.