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Synthesis and Characterization of Neodymium(III) and Gadolinium(III)‐Substituted Hydroxyapatite as Biomaterials
Author(s) -
Li Yan,
Ooi Chui Ping,
Philip Hong Ning Cheang,
Aik Khor Khiam
Publication year - 2009
Publication title -
international journal of applied ceramic technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 57
eISSN - 1744-7402
pISSN - 1546-542X
DOI - 10.1111/j.1744-7402.2008.02293.x
Subject(s) - neodymium , gadolinium , materials science , nanocrystalline material , nuclear chemistry , phase (matter) , nanoparticle , ion , characterization (materials science) , analytical chemistry (journal) , nanotechnology , chemistry , metallurgy , chromatography , organic chemistry , laser , physics , optics
Nanocrystalline hydroxyapatite (HA), Ca 10 (PO 4 ) 6 (OH) 2 , substituted with gadolinium(III) (Gd 3+ ) and neodymium(III) (Nd 3+ ) in different mole ratios (M added /Ca added = X M , 0.01, 0.05, 0.1, and 0.2), was synthesized by an ion‐exchange method. All samples had the single phase of HA except for X M =0.2, which displayed the second phase of M(OH) 3 . All were B‐type carbonated HA. The nanoparticles were elongated spheroids of around 70 nm, and the shape and size did not change significantly with an increase of X M . The M(III)‐doped HA had higher electrical conductivity compared with pure HA. A cytotoxicity test showed all were noncytotoxic except for X Gd =0.2.