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Biodegradation and Cytocompatibility Studies of a Triphasic Ceramic‐Coated Porous Hydroxyapatite for Bone Substitute Applications
Author(s) -
John Annie,
Nair Manitha B.,
Varma H. K.,
Bernhardt Anne,
Gelinsky Michael
Publication year - 2008
Publication title -
international journal of applied ceramic technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 57
eISSN - 1744-7402
pISSN - 1546-542X
DOI - 10.1111/j.1744-7402.2008.02191.x
Subject(s) - materials science , scaffold , human bone , porosity , biomaterial , ceramic , biomedical engineering , biodegradation , mesenchymal stem cell , regeneration (biology) , tissue engineering , isotonic , chemical engineering , composite material , nanotechnology , chemistry , medicine , microbiology and biotechnology , biochemistry , organic chemistry , pathology , in vitro , biology , engineering
Bone defects due to trauma or disease have led to the need for biomaterials as substitutes for tissue regeneration and repair. Herein, we introduce a porous triphasic ceramic‐coated hydroxyapatite scaffold (HASi) for such applications. Interestingly, in the degradation experiments with isotonic buffer, HASi showed a significant release of silica with the disappearance of the tricalcium phosphate phase. Furthermore, the material also exhibited cytocompatibility with cultured bone marrow‐derived mesenchymal stem cells of human origin. The material chemistry, together with the favorable cellular characteristics, indicates HASi as a promising candidate for critical‐size bony defects, which still remains a formidable clinical challenge in the orthopedic scenario.