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Phenylazothioformamide, the active principle in the fungitoxic action of 1‐phenylthiosemicarbazide
Author(s) -
SIJPESTEIJN A. KAARS,
PLUIJGERS C. W.,
VERLOOP A.,
TEMPEL A.
Publication year - 1968
Publication title -
annals of applied biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 80
eISSN - 1744-7348
pISSN - 0003-4746
DOI - 10.1111/j.1744-7348.1968.tb04549.x
Subject(s) - biology , active principle , aspergillus niger , antifungal , action (physics) , botany , biochemistry , microbiology and biotechnology , traditional medicine , medicine , physics , quantum mechanics
SUMMARY Laboratory trials using Aspergillus niger indicate that the antifungal effect of 1‐phenylthiosemicarbazide is based upon its conversion into an oxidation product, phenylazothioformamide. This conversion takes place much more slowly at pH 5 than at pH 7 and is completely prevented by the reducing agent sodium thioglycollate. Both acidity of the medium and the presence of reducing agents lower the fungitoxicity of 1‐phenylthiosemicarbazide.