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The uncoupling of oxidative phosphorylation in pea shoot mitochondria by 3,5‐diiodo‐4‐hydroxybenzonitrile (ioxynil) and related compounds
Author(s) -
KERR M. W.,
WAIN R. L.
Publication year - 1964
Publication title -
annals of applied biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 80
eISSN - 1744-7348
pISSN - 0003-4746
DOI - 10.1111/j.1744-7348.1964.tb01207.x
Subject(s) - oxidative phosphorylation , biology , uncoupling agents , phosphate , shoot , phosphorylation , dinitrophenol , mitochondrion , oxygen , biochemistry , botany , chemistry , organic chemistry
SUMMARY The effect of the new herbicide, ioxynil, and several related compounds, on the oxidative phosphorylation of respiring, isolated pea shoot particles has been studied. Ioxynil and its analogues were found to depress the uptake of inorganic phosphate and, to a lesser extent, of oxygen by the particles; the calculated P/O ratio was eventually reduced to zero. The effect of ioxynil was far greater than that of the well‐known uncoupling agent 2,4‐dinitrophenol and was similar in magnitude to that of the contact herbicide dinitro‐ ortho ‐cresol.