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INTERPRETATION OF DOSAGE‐MORTALITY DATA FOR DDT‐RESISTANT HOUSEFLIES
Author(s) -
HEWLETT P. S.
Publication year - 1958
Publication title -
annals of applied biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 80
eISSN - 1744-7348
pISSN - 0003-4746
DOI - 10.1111/j.1744-7348.1958.tb02176.x
Subject(s) - biology , toxicology , pesticide , probit model , detoxification (alternative medicine) , ecology , statistics , mathematics , medicine , alternative medicine , pathology
The slopes of the lines relating probit mortality to the log.‐dose of DDT are generally lower for resistant than for susceptible strains of houseflies. Two effects that could each account for this are discussed. The first concerns the relation of the amount of DDT absorbed to the dose; the conditions under which it would occur are stated, and published data on the absorption are analysed. The second concerns the variability from fly to fly of the amount of DDT exerting a toxic effect at the primary site of action, a variability that would seem to be brought about, or greatly intensified, by the enzymatic detoxification of DDT in resistant flies. Both mechanisms may occur, reinforcing one another.