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STUDIES IN THE MODE OF ACTION OF INSECTICIDES
Author(s) -
HOPF H. S.
Publication year - 1952
Publication title -
annals of applied biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 80
eISSN - 1744-7348
pISSN - 0003-4746
DOI - 10.1111/j.1744-7348.1952.tb00897.x
Subject(s) - locust , acetylcholine , biology , neostigmine , choline , cholinesterase , toxicology , insect , atropine , organophosphate , physostigmine , cholinergic , carbamate , biochemistry , pharmacology , medicine , endocrinology , pesticide , botany , agronomy
Acetylcholine, choline chloride, acetyl‐β‐methylcholine, benzoylcholine, carbamyl choline, adrenaline and d ‐tubocurarine are non‐toxic when injected into the locust. Prostigmine is also non‐toxic, and eserine considerably less toxic to the locust than to man. The toxic effect of tetraethyl pyrophosphate (TEPP) cannot be antagonized by injection of atropine or enhanced by d ‐tubocurarine. The injection of acetylcholine chloride following injection of TEPP does not affect subsequent mortality. These findings are discussed, and it is suggested that the physiology of the nervous system of the insect is unlike that of the mammal, neither cholinesters nor adrenaline being concerned in it. Phosphorus insecticides are thought to inhibit a general esterase not specifically connected with cholinesters.