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BIOASSAY SYSTEMS FOR THE PYRETHRINS II
Author(s) -
PAGEa A. B. P.,
BLACKITH R. E.
Publication year - 1949
Publication title -
annals of applied biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 80
eISSN - 1744-7348
pISSN - 0003-4746
DOI - 10.1111/j.1744-7348.1949.tb06414.x
Subject(s) - bioassay , sesamin , biology , toxicology , toxicity , chemistry , organic chemistry , ecology , food science
The components of ‘synergistic action’ are reviewed in the light of recent work. It has been shown that for sesamin and isobutylundecylenamide at least, synergistic action remains after physical effects are eliminated. The toxicity of the pyrethrins is increased by a factor of three when up to equimolecular proportions of the above synergists are added, further additions having no effect. It is suggested that a surface complex between synergist and insecticide is formed at the peripheral nerve sheath interfaces, resulting in the reorientation of the pyrethrins molecules to give a more efficient discharge of the resting potential at the interface.