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The Use of Selective Serotonin Reuptake Inhibitors in Children and Adolescents with Major Depression
Author(s) -
Scahill Lawrence,
Hamrin Vanya,
Pachler Mary Ellen
Publication year - 2005
Publication title -
journal of child and adolescent psychiatric nursing
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.331
H-Index - 35
eISSN - 1744-6171
pISSN - 1073-6077
DOI - 10.1111/j.1744-6171.2005.00015.x
Subject(s) - suicidal ideation , psychiatry , clinical trial , depression (economics) , placebo , psychology , randomized controlled trial , medicine , poison control , clinical psychology , suicide prevention , alternative medicine , medical emergency , pathology , economics , macroeconomics
TOPIC: Recent warnings about suicidal thoughts and self‐injurious behavior in youth treated with selective serotonin reuptake inhibitors raise fundamental questions about the risk–benefit ratio of this class of medications.METHODS: Data from placebo‐controlled trials are used to elucidate the potential risks and benefits of the selective serotonin reuptake inhibitors (SSRIs) in children and adolescent with major depression. This analysis forms the basis of clinical recommendations.SOURCES: The review includes the six large‐scale, placebo‐controlled trials that have been published over the past decade. These data were augmented by information from regulatory hearings in 2003–2004 and selected open‐label reports.CONCLUSIONS: Emerging data from several clinical trials show that the SSRIs have modest effects on childhood depression. In addition, SSRI treatment may be associated with behavioral activation, self‐harm, and suicidal ideation. Appropriate use of SSRIs in children and adolescents requires careful diagnostic assessment, evaluation of co‐occurring conditions, and diligent monitoring, especially within the first weeks of treatment.