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Identification of the novel HLA ‐ B *13:02:13 allele in a T aiwanese haematopoietic stem cell donor and the probable HLA haplotype in association with B *13:02:13
Author(s) -
Yang K. L.,
Lee S. K.,
Lin P. Y.
Publication year - 2013
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2012.01154.x
Subject(s) - hla b , microbiology and biotechnology , biology , genetics , haplotype , human leukocyte antigen , allele , antigen , gene
Summary Using sequence‐based typing method, we found a new HLA ‐ B *13:02 variant, B *13:02:13, in a T aiwanese haematopoietic stem cell donor. The DNA sequence of B *13:02:13 is identical to the sequence of B *13:02:01 in exons 2 and 3 except the nucleotide at position 588 where G is replaced by T (codon 172; CTG → CTT ). The DNA sequence variation did not alter the amino acid sequence of B *13:02:01. The generation of B *13:02:13 is thought to derive from B *13:02:01 as a result of a silence mutation. The probable HLA ‐ A , HLA ‐ B and HLA ‐ DRB 1 haplotype in association with B *13:02:1 may be deduced as HLA ‐ A *24‐ B *13:02:13‐ DRB 1*07:01 or HLA ‐ A *02‐ B *13:02:13‐ DRB 1*07:01. The discovery of B *13:02:13 furthers the polymorphism of HLA ‐ B *13 and HLA ‐ B *13:02.