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Recognition of a Caucasoid HLA ‐ B locus allele, B *44:55, in a T aiwanese/ C hinese bone marrow stem cell donor
Author(s) -
Yang K. L.,
Lee S. K.,
Kao R. H.,
Lin C. L.,
Lin P. Y.
Publication year - 2013
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2012.01146.x
Subject(s) - microbiology and biotechnology , exon , nucleotide , bone marrow , biology , hla b , allele , genetics , chemistry , immunology , gene
Summary We detected a C aucasoid HLA ‐ B allele, HLA ‐ B *44:55, in a potential T aiwanese/ C hinese bone marrow hematopoietic stem cell donor during our routine HLA SBT (sequence‐based typing) practice. The sequence of B *44:55 varies with B *44:02:01:01 with one nucleotide in exon 2 at position 97 ( T ‐> C ), while it differs from B *44:03:01 with one nucleotide in exon 2 at position 97 ( T ‐> C ) and three nucleotides in exon 3 at residues 538–540 ( CTG ‐> GAC ). The nucleotide replacements caused one amino acid variation with B *44:02:01:01 at residue 9 ( Y ‐> H ) and two amino acid variations with B *44:03:01 at residue 9 ( Y ‐> H ) and residue 156 ( L ‐> D ). The formation of B *44:55 is probably the result of a nucleotide substitution involving B *44:02:01:01 at position 97 ( T ‐> C ). The Taiwanese/Chinese donor with B *44:55 claims having no kinship with C aucasian. Our speculations on the origin of the T aiwanese/ C hinese B *44:55 will be presented.