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Discovery of the novel HLA ‐ DRB 1*09:01:08 allele in a T aiwanese volunteer bone marrow donor and identification of the probable HLA ‐ A , HLA ‐ B and HLA ‐ DRB 1 haplotype in association with DRB 1*09:01:08
Author(s) -
Yang K. L.,
Lee S. K.,
Yang S. Y.,
Kao R. H.,
Lin C. L.,
Lin P. Y.
Publication year - 2013
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2012.01143.x
Subject(s) - exon , microbiology and biotechnology , human leukocyte antigen , allele , mutation , point mutation , biology , typing , genetics , haplotype , bone marrow , immunology , gene , antigen
Summary We report here the novel variant of HLA ‐ DRB 1*09:01, DRB 1*09:01:08, discovered in a Taiwanese volunteer bone marrow donor by a sequence‐based typing ( SBT ) method. The DNA sequence of DRB 1*09:01:08 is identical to the sequence of DRB 1*09:01:02 in exon 2 except a silent mutation at nucleotide position 261( C → T ) ( GCC → GCT at codon 58). We hypothesize DRB 1*09:01:08 was probably derived from DRB 1*09:01:02 via a nucleotide point mutation event. The plausible HLA ‐A, HLA ‐B and HLA ‐ DRB 1 haplotype in association with DRB 1*09:01:08 was deduced as A *02:07‐ B *46:01‐ DRB 1*09:01:08.