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Association between genetic variants in adhesion molecules and outcomes after hematopoietic cell transplants
Author(s) -
Thyagarajan B.,
Jackson S.,
Basu S.,
Jacobson P.,
Gross M. D.,
Weisdorf D. J.,
Arora M.
Publication year - 2013
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2012.01131.x
Subject(s) - snp , single nucleotide polymorphism , immunology , disease , transplantation , medicine , biology , gene , genetics , genotype
Summary Allogeneic hematopoietic cell transplant ( HCT ) is associated with a high morbidity and mortality. Adhesion molecules play an important role in endothelial activation and initiation of inflammatory response. We hypothesized that single nucleotide polymorphisms ( SNP s) in the endothelial molecules may contribute to heterogeneity in HCT outcomes. We evaluated the association of 4 SNP s in ICAM 1 (rs5498), PECAM 1 (rs668 and rs1131012) and SELL (rs2229569) genes with acute and chronic graft‐versus‐host disease ( G v HD ) and those experiencing transplant‐related mortality ( TRM ) within 1 year among 425 allogeneic HCT recipient–donor pairs. Using a F ine and G ray proportional hazards model to evaluate the association between genetic variants and clinical outcomes, after adjustment for recipient age, race, diagnosis, disease status, gender mismatch, cytomegalovirus serostatus, gender, donor type, conditioning regimen and year of transplant, only rs5498 in the ICAM 1 gene among both recipients and donors was associated with a decreased risk of TRM ( P ≤ 0.02). None of the SNP s were associated with acute or chronic G v HD risk. These findings suggest that genetic variants in the vascular adhesion molecules may be used to identify patients at high risk for TRM .