Premium
Identification of the novel HLA allele, HLA ‐B*40:159, in a T aiwanese hematopoietic stem cell donor and the probable HLA haplotype in an association with B *40:159
Author(s) -
Yang K. L.,
Lee S. K.,
Lin P. Y.
Publication year - 2012
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2012.01130.x
Subject(s) - hla b , genetics , haplotype , biology , human leukocyte antigen , allele , sequence (biology) , exon , hematopoietic stem cell , microbiology and biotechnology , hla b antigens , hla a , haematopoiesis , gene , stem cell , antigen
Summary Using a sequence‐based typing method, we found a new HLA ‐B*40 variant, B *40:159, in a T aiwanese hematopoietic stem cell donor. The sequence of B *40:159 is identical to the sequence of B *40:06:01:01 in exons 2 and 3 except the nucleotides at positions 412 ( A → G ) and 429 ( A → C ). The sequence variation caused two amino acid exchanges at residue 114 ( N → D ) and residue 116 ( Y → S ). The probable HLA ‐ A , HLA ‐ B , HLA ‐ C and HLA ‐ DRB 1 haplotype in association with B *40:159 may be deduced as HLA ‐ A *02:06‐ B *40:159‐ C *08:01‐ DRB 1*08:03. The generation of B *40:159 is thought as the result of a sequence recombination event where B *46:01:01:01, B *15:01:01 or B *15:02:01 donated a minimum length of the DNA sequence from residue 412 to residue 419 to the recipient sequence of B *40:06:01:01.