Identification of the novel HLA allele, HLA ‐B*40:159, in a T aiwanese hematopoietic stem cell donor and the probable HLA haplotype in an association with B *40:159

Summary Using a sequence‐based typing method, we found a new HLA ‐B*40 variant, B *40:159, in a T aiwanese hematopoietic stem cell donor. The sequence of B *40:159 is identical to the sequence of B *40:06:01:01 in exons 2 and 3 except the nucleotides at positions 412 ( A  →  G ) and 429 ( A  →  C ). The sequence variation caused two amino acid exchanges at residue 114 ( N  →  D ) and residue 116 ( Y  →  S ). The probable HLA ‐ A , HLA ‐ B , HLA ‐ C and HLA ‐ DRB 1 haplotype in association with B *40:159 may be deduced as HLA ‐ A *02:06‐ B *40:159‐ C *08:01‐ DRB 1*08:03. The generation of B *40:159 is thought as the result of a sequence recombination event where B *46:01:01:01, B *15:01:01 or B *15:02:01 donated a minimum length of the DNA sequence from residue 412 to residue 419 to the recipient sequence of B *40:06:01:01.