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FcγRIIB‐nt645+25A/G gene polymorphism and periodontitis in Japanese women with preeclampsia
Author(s) -
Wang Y.,
Sugita N.,
Kikuchi A.,
Iwanaga R.,
Hirano E.,
Shimada Y.,
Sasahara J.,
Tanaka K.,
Yoshie H.
Publication year - 2012
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2012.01124.x
Subject(s) - preeclampsia , porphyromonas gingivalis , periodontitis , immunology , genotype , aggregatibacter actinomycetemcomitans , aggressive periodontitis , biology , chronic periodontitis , gene polymorphism , medicine , gene , pregnancy , genetics
Summary FcγRIIB contains a unique immunoreceptor tyrosine‐based inhibition motif (ITIM) and functions as a negative feedback regulator of leucocyte activation and antibody production. We have previously reported FcγRIIB‐nt645+25A/G gene polymorphism to be associated with prevalence and severity of periodontitis, FcγRIIB expression level on peripheral B lymphocytes and the serum IgG level against periodontopathic bacteria. Previous studies have reported maternal periodontal disease to be associated with an increased risk for preeclampsia. Therefore, FcγRIIB‐nt645+25A/G gene polymorphism may be associated with preeclampsia by affecting immune response to periodontopathic bacteria in pregnant women. To elucidate whether FcγRIIB‐nt645+25A/G gene polymorphism has associations with preeclampsia and/or periodontitis in pregnant Japanese women, a case–control study was carried out on women with preeclampsia ( n = 13) and without preeclampsia ( n = 106). Maternal periodontal parameters and bacterial data of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Prevotella intermedia in subgingival plaque were collected within 5 days of delivery. FcγR genotypes of each woman were determined using the genomic DNA isolated from peripheral blood. Serum IgG levels specific for each bacteria were determined. There was a significant association between FcγRIIB‐nt645+25A/G polymorphism and preeclampsia ( P = 0.013). The frequency of the FcγRIIB‐nt645+25AA genotype was higher in the preeclampsia group compared with the nonpreeclampsia group ( P = 0.007). The DNA level of A. actinomycetemcomitans from subgingival plaque was shown to be higher in the preeclampsia group ( P = 0.017). In conclusion, maternal FcγRIIB‐nt645+25A/G polymorphism and subgingival DNA level of A. actinomycetemcomitans were significantly associated with the prevalence of preeclampsia in a limited number of Japanese women independently with periodontal infection. Further investigations should be performed to confirm this association in a larger population and to determine the biological process of the association.