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Discovery of the novel HLA‐DRB1*03:77 allele in a Taiwanese unrelated hematopoietic stem cell donor by a sequence‐based typing method and identification of the probable HLA haplotype in association with DRB1*03:77
Author(s) -
Yang K. L.,
Lee S. K.,
Kao R. H.,
Lin C. L.,
Lin P. Y.
Publication year - 2012
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2012.01110.x
Subject(s) - genetics , biology , human leukocyte antigen , haplotype , allele , typing , sequence (biology) , microbiology and biotechnology , gene , antigen
Summary Here, we report a novel human leucocyte antigen (HLA)‐DRB1 allele, DRB1*03:77, discovered in a Taiwanese unrelated volunteer hematopoietic stem cell donor by a sequence‐based typing (SBT) method. The DNA sequence of DRB1*03:77 is identical to the DNA sequence of DRB1*03:01:01 in exon 2 except one nucleotide at position 223 (G→C). The nucleotide substitution caused an amino acid replacement at residue 46 (E→Q). The formation of DRB1*03:77 was thought as the result of a nucleotide point mutation. The probable HLA‐A, HLA‐B and HLA‐DRB1 haplotype in association with DRB1*03:77 may be deduced as A*33‐B*58‐DRB1*03:77. The donor was a Minna Taiwanese whose ancestors came from mainland China.