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Identification of two novel HLA‐A*02 variants, A*02:319 and A*02:01:64, in two Taiwanese marrow stem cell donors by sequence‐based typing
Author(s) -
Yang K. L.,
Lee S. K.,
Yang S. Y.,
Kao R. H.,
Lin C. L.,
Lin P. Y.
Publication year - 2012
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2011.01080.x
Subject(s) - exon , genetics , biology , haplotype , human leukocyte antigen , allele , typing , microbiology and biotechnology , sequence (biology) , bone marrow , gene , immunology , antigen
Summary We report here two novel variants of HLA‐A*02 allele, A*02:319 and A*02:01:64, discovered in two Taiwanese unrelated volunteer bone marrow donors by sequence‐based typing (SBT) method. The DNA sequence of A*02:319 is identical to A*02:07 in exons 2 and 3 but varies with one nucleotide at codon 9 (TTC‐>TCC). The variation caused one amino acid substitution at residue 9 (F‐>S). On the other hand, the DNA sequence of A*02:01:64 is identical to the sequence of A*02:01:01:01 in exons 2 and 3 except a silent mutation at codon 114 (CAC‐>CAT). The probable HLA‐A, HLA‐B and HLA‐DRB1 haplotypes in association with A*02:319 and A*02:01:64 were deduced as A*02:319‐B*46:01‐DRB1*04 and A*02:01:64‐B*38:02‐DRB1*16:02, respectively.