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Associations of IL‐23R polymorphisms with ankylosing spondylitis in East Asian population: a new case–control study and a meta‐analysis
Author(s) -
Chen C.,
Zhang X.,
Li J.,
Wang Y.
Publication year - 2012
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2011.01067.x
Subject(s) - meta analysis , ankylosing spondylitis , genotyping , medicine , population , snp , single nucleotide polymorphism , traditional medicine , oncology , genetics , biology , genotype , gene , environmental health
Summary Interleukin‐23 receptor (IL‐23R) has been confirmed to be associated with ankylosing spondylitis (AS) in Caucasian. However, whether they are associated with AS in East Asian population remains unidentified. Here, we conducted a new case–control study investigating this relationship in Chinese Han population and then performed a meta‐analysis in East Asian population. The Chinese Han study included 200 cases and 200 controls. Genotyping was completed using the chip‐based matrix‐assisted laser desorption ionization time‐of‐flight mass spectrometry. Allelic associations were analysed using contingency tables. In the meta‐analysis, 1384 cases and 1710 controls from five different studies and the new Chinese Han study were combined using Review Manager software Version 5.1.1. Mantel–Haenszel test was used to calculate fixed effects pooled ORs. No association with AS was observed in the Chinese Han study. Meta‐analysis showed that no SNP was significantly associated with AS in East Asian population. In conclusion, we found no evidence for association between IL‐23R and AS in East Asian population. Major attention should be paid to other genes belonged to IL‐23 signalling pathway network in the future.