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Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis
Author(s) -
HulinCurtis S. L.,
Bidwell J. L.,
Perry M. J.
Publication year - 2012
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2011.01060.x
Subject(s) - haplotype , single nucleotide polymorphism , genetics , allele , genetic variation , gene , osteoarthritis , biology , genotype , medicine , pathology , alternative medicine
Summary We examined single‐nucleotide polymorphisms (SNPs) in IL18 and IL18/R1 genes and knee OA. IL18 rs1946518 wild‐type allele was more frequently observed in cases ( P = 0.04). Haplotype 1 was more frequently observed in cases ( P = 0.04). Genetic variation in the promoter region of IL18, but not IL18R1, may be associated with OA.