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Association of IL‐1β and IL‐6 gene polymorphisms with recurrent spontaneous abortion in a Chinese Han population
Author(s) -
Ma X.,
Xu L.J.,
Wang J.,
Xian M.M.,
Liu M.
Publication year - 2012
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2011.01049.x
Subject(s) - abortion , genetics , gene , haplotype , association (psychology) , chinese population , medicine , biology , allele , genotype , psychology , pregnancy , psychotherapist
Summary As certain cytokines may play a role in unexplained recurrent spontaneous abortion (RSA) and also some cytokine gene polymorphisms may affect the level of cytokine production, the aim of this study was to investigate the relationship between Chinese RSA and polymorphisms of the genes coding for interleukin (IL)‐1β (−31C/T, −511C/T, +3954C/T) and IL‐6 (−634C/G). Women ( n = 162) with at least three consecutive spontaneous abortions and 156 ethnically matched healthy women with at least one successful pregnancy were included. Genotypes were determined using restriction fragment length polymorphism analysis of polymerase chain reaction products. No significant differences were found in the IL‐1β −31T, −511T and +3954T distributions between the RSA group and the control group. On the other hand, the frequencies of the IL‐6 −634GG genotype and −634G allele were significantly decreased in the RSA group versus the control group (genotype: P = 0.0003; allele: P = 0.002), suggesting the IL‐6 −634C/G polymorphism might be a possible genetic protective factor for RSA.