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Description of the new allele HLA‐DQB1*04:03:02
Author(s) -
Longhi E.,
Frison S.,
Mantovani M.,
Carella G.,
Malagoli A.,
Poli F.
Publication year - 2012
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2011.01048.x
Subject(s) - allele , genetics , point mutation , exon , human leukocyte antigen , sequence (biology) , biology , hla dqb1 , polymerase chain reaction , mutation , silent mutation , nucleic acid sequence , microbiology and biotechnology , gene , antigen , missense mutation
Summary A new variant of HLA‐DQB1*04:03 allele officially designated as HLA‐DQB1*04:03:02 was detected in two unrelated Caucasoid individuals by polymerase chain reaction‐sequence‐specific primers and SBT. The new allele nucleotide sequence differs from HLA‐DQB1*04:03:01 for a single silent point mutation in exon 2 at position 159, codon 21.