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Discovery of two novel HLA‐B alleles, B*46:13:03 and B*15:189, in two Taiwanese volunteer bone marrow donors by sequence‐based typing
Author(s) -
Yang K. L.,
Lee S. K.,
Lin C. C.,
Jiang S.,
Chiu H. M.,
Lin S.,
Chen Y. C.,
Yang S. Y.,
Jian Y. F.,
Shyr M. H.,
Lin C. L.,
Lin P. Y.
Publication year - 2011
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2011.01030.x
Subject(s) - hla b , bone marrow , typing , human leukocyte antigen , allele , sequence (biology) , genetics , biology , medicine , microbiology and biotechnology , immunology , antigen , gene
Summary We report here two novel HLA‐B alleles, B*46:13:03 and B*15:189, discovered in two Taiwanese volunteer bone marrow donors. The sequence of B*15:189 has a nucleotide sequence possibly derived from a recombination event between HLA‐B*39:01:01 and B*15:01:01:01, while the origin of the sequence B*46:13:03 was less obvious to postulate, considering the low frequency of B*46:13 in the general population and the silent mutations involved. Our report here adds further HLA polymorphism to the growing lists of HLA‐B*46 and HLA‐B*15 and provides an additional HLA information for donor search programme for patients undergoing transplant.