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Characterization of three novel HLA‐DRB1 alleles, DRB1*03:55, *11:46:02 and *04:92, by exon 2, 3 and 4 sequencing‐based typing
Author(s) -
Balas A.,
GarcíaSánchez F.,
Vicario J. L.
Publication year - 2011
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2011.01020.x
Subject(s) - exon , genetics , allele , typing , biology , nucleotide , gene , hla drb1 , human leukocyte antigen , amino acid , antigen
Summary Sequencing‐based typing of HLA‐DRB1 gene, allowed us to characterize three new alleles. DRB1*03:55 shows one nucleotide change regarding DRB1*03:01:01G, resulting in an amino acid replacement at position 80 R > I. DRB1*11:46:02 presents one synonymous nucleotide change at codon 34 (CAG > CAA) with regard to DRB1*11:46:01. Finally, DRB1*04:92 has one nucleotide change from DRB1*04:07:01 at codon 207 in exon 4, producing an amino acid replacement (V > M) in the transmembrane domain.