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Detection of A B acute lymphoblastic leukaemia blast‐specific mutation in HLA‐B*39:01
Author(s) -
Venigová P.,
Jindra P.,
Koza V.
Publication year - 2011
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2011.01007.x
Subject(s) - mutation , hla b , human leukocyte antigen , exon , biology , hla a , disease , hla b antigens , immunology , genetics , cancer research , medicine , antigen , gene , pathology
Summary Human leucocyte antigen (HLA) modifications observed in blast cells in haematologic malignancies can play an important role in disease progression and its therapy. Here we describe an insertion/deletion mutation in the second exon of HLA‐B*39:01 that occurred in the blast cells of a patient with B‐ALL. This mutation was not present in the nonleukemic cells, in which HLA‐B*39:01 was normally expressed.
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