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Rare HLA alleles and their predicted haplotypes in Tzu Chi Taiwanese marrow donor registry
Author(s) -
Yang K. L.,
Chen M. J.,
Shyr M. H.,
Lin C. L.,
Lin P. Y.
Publication year - 2011
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2010.00992.x
Subject(s) - allele , human leukocyte antigen , haplotype , typing , genetics , biology , bone marrow , medicine , immunology , gene , antigen
Summary The marrow donor registry of Buddhist Tzu Chi Stem Cells Centre (BTCSCC) maintained an HLA database of 291 677 bone marrow volunteer donors from 1993 to 2008. From the 291 677 donors we identified 28 rare alleles and discovered six novel alleles in Taiwanese. Our criterion of a rare allele was according to the definition, set by the National Marrow Donor Program (NMDP),one having a frequency of 0.002% (1/50 000) or less. The authenticity of the rare alleles was confirmed by sequence specific primer (SSP) typing protocol and/or sequence‐based typing (SBT) method. This study reports the number of times the alleles were observed between 1993 and 2008, and the ethnicity of the donors carrying the rare or novel alleles.