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The polymorphism ‐2548 G/A in leptin and severity of Chronic Obstructive Pulmonary Disease
Author(s) -
Ye X.W.,
Xiao M.,
Ye J.,
Zhang X.Y.,
Xiao J.,
Feng Y.L.,
Wen F.q.
Publication year - 2011
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2010.00968.x
Subject(s) - copd , medicine , leptin , odds ratio , genotype , gastroenterology , allele , pathogenesis , spirometry , confidence interval , case control study , gene polymorphism , immunology , biology , gene , asthma , genetics , obesity
Summary Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by airway obstruction that is not fully reversible, and there is evidence of a hereditary component in COPD. We aimed to determine whether the polymorphisms ‐2548G/A of leptin ( LEP ) gene were associated with COPD and its severity in Chinese. A total of 456 subjects with COPD and 422 healthy controls from West China Hospital were enrolled in this study. COPD patients had been undergone a spirometry and a physical examination to refer the GOLD I–IV stages. The polymorphisms in the leptin promoter region at position ‐2548 G/A were detected by Polymerase chain reaction‐restriction fragment length polymorphism analysis. The genotypes and alleles were scored, and the frequencies of the alleles and genotypes in patients and controls were compared. A significantly higher risk for COPD was observed for carriers of the LEP ‐2548 AA genotype [odds ratio (OR) = 7.87, 95% confidence interval (CI) 4.19–14.77, P < 0.001] and carriers of the LEP ‐2548 GA genotype (OR = 2.98, 95% CI 1.57–5.66, P = 0.001). The LEP ‐2548 A allele: frequency was significantly higher in the patient group compared with the control group (OR = 2.75, 95% CI: 2.20–3.44, P < 0.001). We also found a significant relationship between leptin gene polymorphism and the severity of COPD. In the present case–control study, we found an association between the ‐2548 G/A variant of the leptin gene and pathogenesis, severity of COPD in the Chinese population. It suggests that leptin ‐2548 G/A should be used as a genetic marker of COPD severity.