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The association of single nucleotide polymorphism within vascular endothelial growth factor gene with systemic lupus erythematosus and lupus nephritis
Author(s) -
Wongpiyabovorn J.,
Hirankarn N.,
Ruchusatsawat K.,
Yooyongsatit S.,
Benjachat T.,
Avihingsa Y.
Publication year - 2011
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2010.00960.x
Subject(s) - lupus nephritis , vascular endothelial growth factor , genotype , single nucleotide polymorphism , medicine , immunology , allele , nephritis , gene polymorphism , lupus erythematosus , systemic disease , connective tissue disease , gene , vegf receptors , disease , autoimmune disease , biology , genetics , antibody
Summary There were no statistically significant difference in allele and genotype frequency of the polymorphisms within the vascular endothelial growth factor ( VEGF ) gene (−460 and +405) between 193 systemic lupus erythematosus patients and 234 healthy controls. However, the +405 GG was significantly associated with lupus nephritis (LN) patients with low VEGF mRNA expression and LN with end‐stage renal disease.