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IL‐1 receptor antagonist gene polymorphism in idiopathic recurrent spontaneous abortion in a Chinese Han population
Author(s) -
Dai M. Z.,
Pan Y. Q.,
Xu D. P.,
Chen X. J.,
Qian R. J.,
Chen D. H.,
Cui T. W.,
Lin A.,
Yan W. H.
Publication year - 2010
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2010.00939.x
Subject(s) - genotype , interleukin 1 receptor antagonist , allele , variable number tandem repeat , abortion , recurrent miscarriage , genetics , gene polymorphism , polymorphism (computer science) , miscarriage , biology , gene , medicine , receptor antagonist , pregnancy , antagonist , receptor
Summary Interleukin‐1 receptor antagonist (IL‐1Ra) has been supposed to play important roles in pregnancy. The purpose of this study was to evaluate the association between the polymorphisms of IL‐1Ra gene ( IL1RN ) variable number tandem repeat (VNTR) in intron 2 with idiopathic recurrent spontaneous abortion (RSA). Ninety‐two RSA patients and hundred normal women with at least one live birth and no history of miscarriage were included in the study. Frequencies of the IL1RN alleles and genotypes were determined. Data revealed that the prevalence of IL1RN allele and genotype was not significant between the RSA and control group (all P > 0.05). Our finding indicated that the polymorphism VNTR of IL1RN gene in intron 2 may not be a risk factor for RSA in the Chinese Han population.