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Identification of two new HLA‐DRB1 alleles, DRB1*040405 and DRB1*1190
Author(s) -
Mantovani M.,
Longhi E.,
Frison S.,
De Arias A. Espadas,
Mosca A.,
Poli F.
Publication year - 2010
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2010.00934.x
Subject(s) - allele , genetics , biology , point mutation , hla drb1 , exon , human leukocyte antigen , identification (biology) , mutation , gene , antigen , botany
Summary We describe here two novel DRB1 alleles, officially named *040405 and *1190. DRB1*040405 differs from DRB1*0404 for one point mutation at codon 72 with no coding changes. DRB1*1190 is identical to DRB1*110101 except for a nucleotide substitution at codon 24 which causes an aminoacidic mutation from valine to methionine. Over time we have been witnessing the identification of a great number of new HLA alleles. DRB1 allelic variability is mostly present in the second exon and more that 760 alleles have been so far identified. Here, we report the description of two novel DRB1 alleles, named *040405 and *1190, and identified in two Caucasoid subjects.