Premium
AKT1 polymorphisms are associated with tuberculosis in the Chinese population
Author(s) -
Wang X.,
Cao Z.,
Jiang J.,
Zhu Y.,
Dong M.,
Tong A.,
Cheng X.
Publication year - 2010
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2010.00897.x
Subject(s) - single nucleotide polymorphism , genotype , haplotype , tuberculosis , mycobacterium tuberculosis , akt1 , genotype frequency , snp , medicine , pulmonary tuberculosis , biology , immunology , microbiology and biotechnology , genetics , gene , apoptosis , pathology , pi3k/akt/mtor pathway
Summary AKT1, a serine/threonine kinase, plays a critical role in the controlling of intracellular growth of Mycobacterium tuberculosis . In this study, we investigated whether polymorphisms in AKT1 affect susceptibility to tuberculosis (TB). Two single nucleotide polymorphisms of AKT1 , IVS3+18C>T and +726G>A were genotyped in Chinese patients with pulmonary TB by polymerase chain reaction‐restriction fragment length polymorphism. Patients with pulmonary TB had significantly lower IVS3+18 C/C genotype and higher C/T genotype compared with age‐, gender‐ and ethnically matched controls ( P < 0.05). The T–A haplotype frequency was significantly higher in patients than in controls ( P < 0.05). In conclusion, our result indicates that AKT1 polymorphisms are associated with susceptibility to pulmonary TB.