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Functional polymorphism of cytotoxic T‐lymphocyte antigen 4 and nasopharyngeal carcinoma susceptibility in a Chinese population
Author(s) -
Xiao M.,
Qi F.,
Chen X.,
Luo Z.,
Zhang L.,
Zheng C.,
Hu S.,
Jiang X.,
Zhou M.,
Tang J.
Publication year - 2010
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2009.00888.x
Subject(s) - cytotoxic t cell , ctla 4 , genotype , immunology , cd80 , biology , antigen , cd86 , cd28 , cd8 , t cell , genetics , immune system , gene , cd40 , in vitro
Summary Cytotoxic T‐lymphocyte antigen 4 (CTLA‐4; CD152) is a secondary receptor of B7 (CD80 and CD86) and shares homology with the CD28 receptor. Although the structures of CTLA‐4 and CD28 are very similar, they deliver different costimulatory signals. A functional polymorphism in CTLA‐4 exon 1 position +49 that can affect the T‐cell response has been reported by several groups. Previous case–control studies also revealed this polymorphism contribute to the risk of autoimmune diseases and common cancers. However, the relationship between CTLA‐4 functional polymorphism and nasopharyngeal carcinoma (NPC) susceptibility has not yet been explored. In this study, we performed a case–control study in a Chinese population. Our result showed that the CTLA‐4 +49 A>G polymorphism is associated with NPC susceptibility. The subjects carrying the CTLA‐4 +49 AA genotype have a ∼1.8‐fold increased risk of NPC (adjust OR 1.83; 95% CI, 1.16–2.93) when compared with the GG genotype.