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Gene polymorphism in transforming growth factor‐beta codon 10 is associated with susceptibility to Giardiasis
Author(s) -
Taherkhani H.,
Hajilooi M.,
Fallah M.,
Khyabanchi O.,
Haidari M.
Publication year - 2009
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2009.00873.x
Subject(s) - genotype , asymptomatic , odds ratio , allele , medicine , biology , polymorphism (computer science) , antibody , immunology , gene polymorphism , immunoglobulin a , gastroenterology , gene , immunoglobulin g , genetics
Summary Secretory immunoglobulin A (S‐IgA) antibodies have a central role in anti‐Giardial defence. It has been demonstrated that transforming growth factor‐beta1 (TGF‐β1) stimulates B lymphocytes to produce and secrete S‐IgA. We sought to determine the association between TGF‐β1 polymorphism (T+869C) with susceptibility to Giardiasis. The TGF‐β1 genotypes and levels of salivary (S‐IgA) were analysed in individuals with Giardiasis (97 symptomatic and 57 asymptomatic) and controls ( n = 92). Individuals with symptomatic Giardiasis had the lowest levels of S‐IgA compared to individuals in asymptomatic Giardiasis and control groups (97%, 73% and 43%, <1 g L −1 , respectively, P = 0.002). The frequency of allele C and CC genotypes of TGF‐β1 polymorphism was significantly higher among symptomatic patients than asymptomatic and control groups. Logistic regression analysis demonstrated that the individuals homozygous for allele C of TGF‐β1 had a significantly higher risk for symptomatic Giardiasis with odds ratio of 2.76 (95% CI: 3.88, 1.71, P = 0.007). Among the participants with TT genotype per cent of individuals with S‐IgA level of more than 1 g L −1 was almost twice the percentage in CC genotype individuals (14% versus 7% respectively P = 0.01). Our data suggest that CC genotype of TGF‐β1 polymorphism at codon 10 is associated with occurrence of Giardiasis.