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Detection of a novel HLA‐B27 allele, B*2740, in Taiwanese volunteer bone marrow donors by sequence‐based typing: curiosity rewarded
Author(s) -
Chen M. J.,
Yang T. C.,
Chu C. C.,
Shyr M. H.,
Lin C. L.,
Lin P. Y.,
Yang K. L.
Publication year - 2009
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2009.00849.x
Subject(s) - allele , genetics , human leukocyte antigen , valine , gene , epitope , nucleic acid sequence , biology , microbiology and biotechnology , amino acid , antibody , antigen
Summary We report here a novel HLA‐B allele, B*2740, discovered in Taiwanese volunteer marrow donors. The new sequence has nucleotide variation at position 527 (T→A) as compared to B*2708. The nucleotide change caused an amino acid substitution from valine (V) to glutamic acid (E) at codon 152. Since B*2740 carries sequence confers to HLA‐Bw6 public epitope we believe that this novel B*27 allele might have been generated from a gene conversion involving a Bw4‐specific allele (probably B*2704) and a Bw6‐specific allele.