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The CTLA4 +49 A/G polymorphism is not associated with susceptibility to type 1 diabetes mellitus in the Portuguese population
Author(s) -
Lemos M. C.,
Coutinho E.,
Gomes L.,
Bastos M.,
Fagulha A.,
Barros L.,
Carrilho F.,
Geraldes E.,
Regateiro F. J.,
Carvalheiro M.
Publication year - 2009
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2009.00844.x
Subject(s) - portuguese , polymorphism (computer science) , genetics , type 2 diabetes mellitus , diabetes mellitus , gene , type 2 diabetes , gene polymorphism , population , biology , medicine , genotype , endocrinology , philosophy , linguistics , environmental health
Summary CTLA4 genetic polymorphisms have been associated with type 1 diabetes. We genotyped 207 patients and 249 controls for the most frequently investigated polymorphism of the CTLA4 gene (+49A/G (rs231775)). No significant differences were observed, suggesting that this polymorphism is not strongly associated with type 1 diabetes in the Portuguese population.