Premium
Cytotoxic T lymphocyte‐associated molecule‐4 polymorphism in Turkish patients with Hashimoto thyroiditis
Author(s) -
Sahin M.,
Gursoy A.,
Erdogan M. F.
Publication year - 2009
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2009.00831.x
Subject(s) - thyroiditis , cytotoxic t cell , turkish , immunology , medicine , polymorphism (computer science) , lymphocyte , biology , genetics , thyroid , genotype , gene , in vitro , philosophy , linguistics
Summary We previously shown that in a Turkish population, the A/G polymorphism in exon 1 of the cytotoxic T cell lymphocyte‐associated molecule‐4 (CTLA‐4) gene is associated with Graves’ disease, and that the G allele may contribute to susceptibility for developing Graves’ disease. This polymorphism was identified in 197 patients with Hashimoto thyroiditis (HT) (126 women, 71 men; aged, 42.92 ± 13.4 years) and 98 healthy individuals (56 women, 21 men; aged, 42.27 ± 13.43 years) in Turkish population. Polymorphisms were analysed using a polymerase chain reaction–restriction fragment length polymorphism method. Frequency of the A/G genotypes was not significantly different in patients with HT when compared with controls in both sexes ( P > 0.05). There was no statistical difference in age, sex, cigarette smoking, initial serum thyroid hormone levels, initial goiter size and thyroid autoantibodies among the patients with the three different genotypes (G/G, A/G and A/A). We concluded that A/G polymorphism of CTLA molecule is linked to occurence of Graves’ disease bu not to HT in the Turkish population.