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Identification of a novel HLA‐A allele, A*1131, in a Taiwanese
Author(s) -
Chen M. J.,
Chu C. C.,
Shyr M. H.,
Lin P. Y.,
Yang K. L.
Publication year - 2009
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2008.00827.x
Subject(s) - exon , allele , genetics , nucleotide , biology , amino acid substitution , human leukocyte antigen , microbiology and biotechnology , amino acid , identification (biology) , gene , mutation , antigen , botany
Summary Here we report the identification and sequence analysis of a new HLA‐A11* variant, A*1131 allele, found in a Taiwanese volunteer bone marrow donor. The novel A*11 variant is identical to A*1125 in exon 2 but differs from A*1125 in exon 3 by one nucleotide substitution at position 527 causing an amino acid change at codon 152 E→V (GAG→GTG). In comparison with HLA‐A*110101, allele A*1131 has three nucleotide differences in exon 3: 527 C→T, 538 C→T and 539 A→T leading to two amino acid variations at residues 152 A→V and 156 Q→L.