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A comparative analysis of the products of GROEL‐1 gene from Chlamydia trachomatis serovar D and the HSP60 var1 transcript from Homo sapiens suggests a possible autoimmune response
Author(s) -
Campanella C.,
Marino Gammazza A.,
Mularoni L.,
Cappello F.,
Zummo G.,
Di Felice V.
Publication year - 2009
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2008.00819.x
Subject(s) - chlamydia trachomatis , autoimmunity , hsp60 , groel , biology , epitope , chlamydia , serotype , gene , immunology , virology , genetics , heat shock protein , immune system , antibody , escherichia coli , hsp70
Summary Chlamydia trachomatis serovar D produces large quantities of HSP60‐1 during infections, which accumulate inside the host cell inducing autoimmunity. We compare the aminoacid sequences of the human HSP60 with the bacterial counterpart to better elucidate how CTHSP60 may simulate HSP60 from human origin during infection and may induce an autoimmune response. As a result of the comparison we suggest several possible epitopes of the CTHSP60, which may induce autoimmunity.