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MCP‐1 and CCR2 gene polymorphisms in Czech patients with allergic disorders
Author(s) -
Izakovicova Holla L.,
Mrazek F.,
Petrek M.
Publication year - 2009
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2008.00816.x
Subject(s) - immunology , genotype , allergy , allele , ccr2 , pathogenesis , asthma , sensitization , phenotype , gene , medicine , genetics , biology , chemokine , chemokine receptor , inflammation
Summary Several lines of evidence suggest that chemokines play an important role in asthma and allergy. We analysed polymorphisms at –2518A/G and –2076A/T of MCP‐1 and V64I of CCR2 gene in healthy subjects ( n = 306) and allergic patients ( n = 332). Allele and genotype frequencies did not differ significantly between groups. Nevertheless, MCP‐1 variants were associated with allergen sensitization. The results suggest that MCP‐1, but not CCR2 gene variants, may participate in the pathogenesis of allergic phenotypes at least in the Caucasian population.