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Identification of two novel HLA‐DRB1 alleles, HLA‐DRB1*1214 and HLA‐DRB1*1215, in two Taiwanese individuals
Author(s) -
Lee H. L.,
Chu C. C.,
Trejaut J. A.,
Yang K. L.,
Lin M.
Publication year - 2008
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2008.00785.x
Subject(s) - hla drb1 , genetics , exon , allele , human leukocyte antigen , biology , gene , transition (genetics) , typing , antigen
Summary Two novel HLA‐DRB1 alleles, HLA‐DRB1*1214 and HLA‐DRB1*1215, were found in Taiwan using sequence‐based typing method. DRB1*1214 differs from DRB1*120101 by two nucleotide substitutions on exon 2, causing amino acid changes at codon 37 (L→F) and codon 38 (L→V). We suggest that DRB1*1214 is the product of a gene conversion between DRB1*120101 and DRB1*140101 or DRB1*1405 and that HLA‐DRB1*1215 differs from DRB1*120201 by one single nucleotide transition at exon 2, thereby causing amino acid change at codon 37 (L→F).