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FCER1A gene proximal promoter polymorphisms in Caucasians and East Asians
Author(s) -
Potaczek D. P.,
Sanak M.,
Nishiyama C.,
Okumura K.,
Ogawa H.,
Szczeklik A.
Publication year - 2008
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2008.00784.x
Subject(s) - haplotype , genetics , promoter , locus (genetics) , gene , biology , polymorphism (computer science) , allele , microbiology and biotechnology , gene expression
Summary Two FCER1A gene proximal promoter polymorphisms, –344C > T and –95T > C, both associated with total serum IgE and/or allergic disorders in Caucasians and East Asians, were shown to influence the gene expression in additive manner. In face of the rarity of other proximal promoter variants in Caucasians or their lack in East Asians, future investigations of the FCER1A locus in these ethnic groups should probably focus on three common haplotypes of the common –344C > T and –95T > C polymorphisms.