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Characterization of two novel HLA class I alleles: HLA‐A*310103 and HLA‐B*9531
Author(s) -
Frison S.,
Longhi E.,
Andreini E.,
Poli F.,
Scalamogna M.
Publication year - 2008
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2008.00761.x
Subject(s) - human leukocyte antigen , allele , genetics , exon , hla a , biology , typing , transplantation , hla b , mutation , hla c , gene , antigen , medicine , surgery
Summary Two novel human leucocyte antigen (HLA) class I alleles were characterized by means of sequencing‐based typing techniques. HLA‐A*310103 was identified in a cord blood unit from a Caucasoid individual. The sequence of this allele is identical to that of HLA‐A*310102 except for a silent mutation in exon 3 at position 480 (G → A). HLA‐B*9531 was found in a Caucasoid female patient registered on the heart transplantation waiting list in the North Italy Transplant programme. This new variant differs from HLA‐B*1503 at position 572 (G → C) in exon 3. This nucleotide change leads to an amino acidic substitution at codon 167 from tryptophan to serine.