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The genetic differences with whole genome linkage disequilibrium mapping between responder and non‐responder in interferon‐α and ribavirin combined therapy for chronic hepatitis C patients
Author(s) -
Chen P.J.,
Hwang Y.,
Lin C. G.J.,
Wu Y.J.,
Wu L. S.H.
Publication year - 2008
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2008.00754.x
Subject(s) - ribavirin , linkage disequilibrium , genotyping , interferon , hepatitis c , single nucleotide polymorphism , allele , medicine , chronic hepatitis , biology , virology , immunology , genetics , genotype , gene , virus
Summary Interferon‐α and ribavirin combined therapy has been a mainstream treatment for hepatitis C infection. The efficacy of this combined treatment is around 30% to 60%, and the factors affecting the responsiveness are still poorly defined. Our study is intended to investigate the genetic differences between responder and non‐responder patients. The genome‐wide linkage disequilibrium screening for loci associated with genetic difference between two patient groups was conducted by using 382 autosomal short tandem repeat (STR) markers involving 92 patients. We have identified 19 STR markers displaying different allele frequencies between the two patient groups. In addition, based on their genomic location and biological function, we selected the CD81 and IL15 genes to perform single nucleotide polymorphism genotyping. In conclusion, this study may provide a new approach for identifying the associated polymorphisms and the susceptible loci for interferon‐α and ribavirin combined therapy in patients with chronic hepatitis C.