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Extensive gene conversion between CCR2 and CCR5 in domestic cat ( Felis catus )
Author(s) -
Esteves P. J.,
Abrantes J.,
Van Der Loo W.
Publication year - 2007
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2007.00716.x
Subject(s) - felis catus , biology , ccr2 , gene , extracellular , chemokine receptor , cats , lineage (genetic) , genetics , receptor , microbiology and biotechnology , chemokine , ecology , medicine , predation
Summary Homogenization of the CC‐motif chemokine receptors CCR2 and CCR5 of cat ( Felis catus ) is documented and shown to be the outcome of gene conversion within the feline lineage. All regions were concerned, except the three extracellular protein domains (N‐ and C‐tails, and ECL2), suggesting that structural differentiation at these domains could be related to pathogen susceptibility.