Premium
Promoter polymorphism of IL‐18 gene in pulmonary tuberculosis in South Indian population
Author(s) -
Harishankar M.,
Selvaraj P.,
Rajeswari D. N.,
Anand S. P.,
Narayanan P. R.
Publication year - 2007
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/j.1744-313x.2007.00714.x
Subject(s) - haplotype , genotype , allele , promoter , gene , tuberculosis , biology , polymerase chain reaction , genetics , polymorphism (computer science) , allele frequency , immunology , pulmonary tuberculosis , genotype frequency , immunity , medicine , gene expression , immune system , pathology
Summary Interleukin‐18 (IL‐18) plays a vital role in both innate and acquired immunity. We analysed polymorphisms at –607(C/A) and –137(G/A) in the promoter region of IL‐18 gene by allele‐specific polymerase chain reaction in normal healthy subjects ( n = 173) and patients with pulmonary tuberculosis ( n = 165). Allele, genotype and haplotype frequencies did not differ significantly between normal healthy subjects and patients. The results suggest that the IL‐18 gene promoter polymorphisms are not associated with susceptibility or resistance to pulmonary tuberculosis in south Indian population of Dravidian descent.